Bioweb

The development of this BioWeb site was supported by grants from AcITAC and The Foundation of UMDNJ. The site is under continuous expansion and revision. For comments and permission to use this material please contact Dr. S. Kumar.
PowerPoint slides are available only when the course is
scheduled (January to June) every year. All slides may not be available at     all times. Please e-mail Dr. Kumar if you have problems.
 Glossary of biochemical terms 
Frequently Asked Questions (FAQs)

 Dental Biochemistry-2014 
   Syllabus and Lecture Schedule
   Lecture Schedule 2014
  
Lecture Slides
   
For Exam I

  
Lecture1- Kumar

  
  Lec 2--Kumar
   Lecture 3-Kumar
   Lecture 4-Kumar
   Lecture 5- kumar
   Lecture 6- Kumar
   Lecture 7--kumar
   Lecture 8 -Kumar
   Lecture 9-lea
   Lecture 10-Dr. Lea
   Lecture 11-Dr. Lea
   Lecture 12-Dr. Lea
   Lecture 13-Dr. Lea
   Lecture 14-Dr. Lea
   lecture 15- Dr. Kumar
   Lecture 16- Dr. Kumar
   Lecture 17- Dr. Kumar
   Lecture 18- Dr. Lea

     
     For Exam II
  Lecture 19-Suzuki
   Lecture 20-Suzuki
  
Lecture 21-Kumar
   Lecture 22-Lutz
   lecture 23-25-Cunningham
   Lecture 26 christakos
  
Lecture 27- Birge

 
  Lecture 28-Kumar

 
Lecture 29-birge
   Lecture 30-Birge

   Lecture 31 Modak
   Lecture 32 Modak

   Lecture 33-34 Modak
   Lecture 35-Suzuki
    Lecture 36-Howells
   Lect 37 Howells

For Exam III
 Lecture 38-oncogenes-howells
  Lecture 39-AIDS-Modak
  Lecture 40-Neurobiochemistry-howells
  Lecture 41-Blood clotting-christakos
  Lecture 42,43-heme and hemoglobin-lea
  Lecture 44-Complex carbohydrates-lutz
  Lecture 45-Connective tissue-lutz
  Lecture 46-bisphosphonates-kumar
  Lecture 47-no slides
  Lecture 48-Biochemistry of teeth-O'connor
  Lecture 49-Bone formation -O'connor
  Lecture 50-Mineral metabolism-christakos
  Lectures 51,52-vitamins-lea
  Lecture 53-artificial sweeteners-mo
dak

Key Exam I
  

  Practice Questions Exam I 
  
PBLs
      PBL Groups
     PBL I
     PBL II
     PBL III
   


    Practice Questions
   Exam II practice questions

  
   Reading assignment

  Biochemical and Molecular  Mechanism of  action of Bisphosphonates

Teaching Faculty  for Dental Biochemistry
  Birge NJMSLee NJMS
           
Dr. Birge              Dr. Lee                   Dr. Christakos        Dr. Cunningham
  
kumar NJMS
Dr. Lea
          Dr. Howells         Dr. Kaushik-Basu    Dr. Kotenko          Dr. Kumar             Dr. Lea

  Dr. Modak
Dr. PandeyDr. Suzuki
          Dr. Lutz              Dr. Modak.                Dr. O'Connor           Dr. Pandey      Dr. Suzuki



News and Views




  Pre-knowledge
Biochemistry Overview

  Chemical Bonds
  Thermodynamics
  Functional Groups
  Stereochemistry
  Basic Chemical Reactions
  pH and Buffer Action
  Amino Acids

Enzymes

Basics
Coenzymes and Cofactors
Isoenzymes
Enzyme properties
  Graduate Courses
 1. Enzyme Kinetics and Mechanism
 
Protein Structure

   Quizzes for Graduate  Kinetics
         
Enzyme catalysis quizzes
         
Enzyme mechanism tutorial

  2. 
Enzyme inhibitors in Drug discovery
  3. Angiogenesis
 
   Dr. Suriender Kumar           r         
                                                
Najjar             Boccabella             Kumar
Preview

I received my B.Sc (Honors) and M.Sc in chemistry from Delhi University in 1960 and Ph.D.
from Boston University in 1967 under the direction of Dr. George Hein. I was a post doctoral fellow with Dr. George Hess (a member of the national academy of sciences) at  Cornell and a research associate with Dr. John Porter at University of Wisconsin at Madison. In 1971, I joined the then CMDNJ at Newark as an assistant professor and was promoted to professor in 1981. Although I was trained as an enzymologist, I have published in various fields of research including enzymology, cell transformation and mechanism of  bone formation and bone resorption. Over the years, I have had numerous research grants, have had around 12 postdoctoral fellows trained in my laboratory, and have published and reviewed many papers in prestigious journals, including one major theoretical paper. More recently I have concentrated my efforts in teaching and service. At New Jersey Medical School I have been a course director for Medical Biochemistry and I have been course director for Dental Biochemistry for the past 12 years. I have interviewed candidates for admission to NJMS Medical School admissions committee and have been on the admissions committee at NJ Dental School for the past ~10 years. I have served on numerous faculty 
committees.

Selected Publications
Alok K. Upadhyay, Nootan Pandey, Suriender Kumar and Virendra N. Pandey. Role of Tryptophan 24 and Phenylalanine 61 of HIV-1 RT in template positioning, fidelity and conferring drug sensitivity to the enzyme. (2010). Global J. Biochem. 1, 1-17
B. Sharma, N. Kaushik, K. Singh, S. Kumar, and V. N. Pandey.(2002) Substitution of Conserved Hydrophobic Residues in Motifs B and C of HIV-1 RT Alters the Geometry of Its Catalytic Pocket. Biochemistry 41, 15685-15697.
P.K. Pandey, N. Kaushik, D. Harris, B. Sharma, K. Singh, S. Kumar and V.N. Pandey. (2002). Insertion of a small peptide of 6 amino acids in the b7-b8 Loop of the p51 Subunit of HIV-1 Reverse Transcriptase Prevents Dimerization and Disrupts Enzymatic Activities. BMC-Biochemistry 3(1): 18
Chang, K.M., Rani, S., Chang, K.C. and Kumar, S. (1996) Plasminogen activator activity is decreased in rat gingiva during diabetes. J. Periodontology, 67, 743-747
 Panagakos, F.S., Jandinski, J.J., Feder, L., and Kumar, S. (1995) Heparin fails to potentiate the effects of IL-1¿-mediated bone resorption of fetal rat long bones in vitro. BIochemie, 77, 915-918. Panagakos, F.S., Fernandez, C., and Kumar, S. (1996) Ultrastructural analysis of mineralized matrix from human osteoblastic cells: Effects of tumor necrosis factor-¿. Mol. Cell. Biochem. 158, 81-89.
Shah, V. and Kumar, S. (1994) Metastasis of human colon tumor cells in vitro: Correlation with the overexpression of plasminogen activators and 72-kDa gelatinase. In Vivo, 8, 321- 326.
Panagakos, F.S., Hinojosa, L.P. and Kumar, S. (1994) Formation and mineralization of extracellular matrix secreted by an immortal human osteoblastic cell line: Modulation by tumor necrosis factor-alpha. Inflammation, 18, 267-283.
Rani, A.S., Qu, D.Q., Sidhu, M.K., Panagakos, F., Shah, V., Klein, K., Brown, N., Pathak, S. and Kumar, S. (1993) Transformation of immortal non-tumorigenic osteoblast like human osteosarcoma cells to the tumorigenic phenotype by nickel sulfate. Carcinogensis, 14, 947- 953.
Rani, A., Shobha and Kumar, S. (1992) Transformation of nontumorigenic osteoblast-like human osteosarcoma cells by hexavalent chromates: Alteration of morphology, induction of anchorage-independence and proteolytic function. Carcinogenesis, 13, 2121-2027.
Kumar, S. (1982) A model for the mechanism of action of animal fatty acid synthases. J. Theor. Biol., 95, 263-283.