Both Kazama et al. and Soria et al. (cited in 1) have reported plasminogen deficiency and dysplasminogenemia with thrombotic disorders. Similarly, abnormalities in plasminogen activator have been associated with retinal venous occlusion. The release of t-PA from the endothelium initiates intravascular fibrinolysis, which is also regulated by its inhibitor, plasminogen activator inhibitor-I.