UNIVERSITY OPHTHALMOLOGY CONSULTANTS
 

CASE OF THE MONTH

CASE #3

 

HISTOPATHOLOGY OF EXCISED CNV

 

  FIGURE 3A   FIGURE 3B  
  Histology of excised CNV   EM of excised CNV  
         
  Histologically, the excised CNV disclosed a specimen consisting of a vascular component and a collagenous scar (Figure 3A). Hyperplastic RPE lined the surface of the scar, and probable RPE was present in the interior of the scar. Electron microscopy showed discontinuous basement membrane lining the surface of the scar (Figure 3B).
   
  FIGURE 3C   FIGURE 3A  
  Histology of excised CNV   Histology of excised CNV  
         
  The vascular component of the CNV contained well-defined vascular channels centrally (Figure 3C) and was surrounded by RPE (Figure 3A).  
     
  FIGURE 3D   FIGURE 3E  
  Histology of excised CNV   Histology of excised CNV  
         
  Clumps of hyperplastic RPE, basement membrane (Figures 3D and E), and widely spaced collagen (Figure 3E) were also present. Neither the collagenous components of Bruch’s membrane nor the choriocapillaris were noted in the specimen.
   
OUTCOME
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