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Basic Chemical Reactions of Biomolecules

Reaction Types
Reaction
What Happens
Example in the Body
Oxidation/Reduction
Oxidation is the removal of electron(s). The electron(s) are passed to the other reactant which is then "reduced." For more details, see Redox Reactions from Boyer's Biochemistry. Glycolysis, the Krebs Cycle, and the reactions of the Electron Transport Chain involve the transfer of electrons (at varying energy states) by oxidation/reduction reactions.
Hydrolysis Cleavage of a bond by water. The water is added in the reaction. A disaccharide (sucrose) reacts with water and two monosaccharides are formed.
Dehydration or Condensation See dehydration synthesis vs. hydolysis. Disaccharide are formed by combination of two monosaccharides by dehydration synthesis.
Decarboxylation The removal of a CO2 from a molecule. The oxidative decarboxylation of pyruvate in the Krebs Cycle. Products are acetyl CoA, NADH and CO2.
Phosphorolysis Cleavage of a bond by inorganic phosphate (phosphoric acid). Glycogen phosphorylase utilizes inorganic phosphate (phosphorolysis) to produce glucose1-phosphate.
The advantage of phosphorolytic cleavage is that glucose-1-phosphate is formed without the need for ATP, and the concentration of inorganic phosphate (Pi) is high enough to drive the reaction in the favorable direction.
Phosphorylation The transfer of a phosphate group to an organic molecule. The synthesis of ATP from ADP and inorganic phosphate.
Transamination The removal of the amino group from the amino acid. The amino group is then "put on" a keto acid. Transamination occurs before deamination and is useful in the removal of excess nitrogen, and in teh use of amino acids in the TCA cycle. For more on Amino Acid Metabolism (from Ngee Ann Polytechnic, Singapore).
Deamination The removal of an amino group. Digested proteins (amino acids) enter the citric acid cycle after removal of amino groups.
Esterification Carboxylic acid reacts with alcohol.  
Transmethylation    

Coupled Reactions
Reaction
Example
Decarboxylation and oxidation/reduction    

 

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